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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK2
All Species:
49.09
Human Site:
T221
Identified Species:
67.5
UniProt:
P24941
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P24941
NP_001789.2
298
33930
T221
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
Chimpanzee
Pan troglodytes
XP_523720
325
36841
T241
R
I
F
R
M
L
G
T
P
S
E
D
T
W
P
Rhesus Macaque
Macaca mulatta
XP_001113345
298
33812
T221
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
Dog
Lupus familis
XP_856049
298
33839
T221
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
Cat
Felis silvestris
Mouse
Mus musculus
P97377
346
38960
T269
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
Rat
Rattus norvegicus
Q63699
298
33869
T221
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P13863
303
34670
T222
R
I
F
R
A
L
G
T
P
N
N
D
V
W
P
Frog
Xenopus laevis
P23437
297
33852
T221
R
I
F
R
T
L
G
T
P
D
E
V
S
W
P
Zebra Danio
Brachydanio rerio
NP_998571
298
34001
T221
R
I
F
R
T
L
G
T
P
D
E
S
I
W
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23573
314
35870
T224
R
I
F
R
T
L
S
T
P
D
E
T
N
W
P
Honey Bee
Apis mellifera
XP_393450
299
34033
T220
R
I
F
R
T
L
G
T
P
D
E
N
I
W
P
Nematode Worm
Caenorhab. elegans
P34556
332
38277
T240
R
I
F
R
V
L
G
T
P
T
E
L
E
W
N
Sea Urchin
Strong. purpuratus
XP_790847
299
34142
T221
R
I
F
R
T
M
G
T
P
D
E
K
L
W
P
Poplar Tree
Populus trichocarpa
XP_002306004
294
33768
K215
S
E
I
D
E
L
F
K
I
F
R
I
L
G
T
Maize
Zea mays
P23111
294
33816
K215
S
E
I
D
E
L
F
K
I
F
R
I
L
G
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
K215
S
E
I
D
Q
L
F
K
I
F
R
I
M
G
T
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
F222
D
S
E
I
D
Q
I
F
K
I
F
R
V
L
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69.8
99.6
98.9
N.A.
85.2
98.6
N.A.
N.A.
65.3
88.9
90.2
N.A.
62.7
69.9
56.9
75.9
Protein Similarity:
100
79.6
99.6
99.6
N.A.
85.8
99.6
N.A.
N.A.
77.8
94.9
94.9
N.A.
74.8
82.2
69.8
88.6
P-Site Identity:
100
73.3
100
100
N.A.
100
100
N.A.
N.A.
73.3
93.3
86.6
N.A.
80
86.6
66.6
80
P-Site Similarity:
100
73.3
100
100
N.A.
100
100
N.A.
N.A.
80
93.3
93.3
N.A.
80
93.3
73.3
93.3
Percent
Protein Identity:
66.4
66.7
N.A.
67.1
62.4
N.A.
Protein Similarity:
83.2
82.2
N.A.
81.5
79.1
N.A.
P-Site Identity:
6.6
6.6
N.A.
6.6
6.6
N.A.
P-Site Similarity:
20
20
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
6
0
0
18
6
0
0
0
0
59
0
12
0
0
0
% D
% Glu:
0
18
6
0
12
0
0
0
0
0
71
0
6
0
0
% E
% Phe:
0
0
77
0
0
0
18
6
0
18
6
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
71
0
0
0
0
0
0
18
6
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
77
18
6
0
0
6
0
18
6
0
18
12
0
0
% I
% Lys:
0
0
0
0
0
0
0
18
6
0
0
6
0
0
0
% K
% Leu:
0
0
0
0
0
89
0
0
0
0
0
6
18
6
0
% L
% Met:
0
0
0
0
6
6
0
0
0
0
0
0
6
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
6
6
6
6
0
6
% N
% Pro:
0
0
0
0
0
0
0
0
77
0
0
0
0
0
71
% P
% Gln:
0
0
0
0
6
6
0
0
0
0
0
0
0
0
0
% Q
% Arg:
77
0
0
77
0
0
0
0
0
0
18
6
0
0
0
% R
% Ser:
18
6
0
0
0
0
6
0
0
6
0
6
6
0
0
% S
% Thr:
0
0
0
0
59
0
0
77
0
6
0
6
6
0
18
% T
% Val:
0
0
0
0
6
0
0
0
0
0
0
36
42
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
77
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _